SUBSTITUTED PTERIDINONES, PYRIMIDINES, PYRROLOPYRIMIDINES, AND PURINES AS P90 RIBOSOMAL S6 PROTEIN KINASE-2 (RSK2) INHIBITORS: PHARMACOPHORE MODELING DATA

The RSK2 kinase is a downstream effector of the Ras/Raf/MEK/ERK pathway that is aberrantly Wings active in a range of cancer types and has been recognized an anticancer target.The inhibition of RSK2 kinase activity would disrupt multiple pro-cancer processes; however, there are few RSK2 inhibitors.The data have been obtained for a series of pteridi

Tungiasis is Pain Relief caused by the jigger flea Tunga penetrans.We describe a case of severe infestation from Kigoma region, Western Tanzania.A 19-year-old male with epilepsy and mental disability presented with ulcerated and inflamed toes.Clinical examination revealed the presence of approximately 810 embedded jigger fleas on the feet, and anot

This article gives very significant Canine - Bandanas - Christmas and up-to-date analytical results on the conductive-radiative heat transfer model containing two conducting and opaque materials which are in contact by radiation through a transparent medium bounded by diffuse-gray surfaces.Some properties of the radiative integral operator will be